Incidence, risk factors and prognostic impact of cytomegalovirus infection after heart transplantation. / Incidencia, factores de riesgo e impacto pronóstico de la infección por citomegalovirus tras el trasplante cardiaco.
Med Clin (Barc)
; 154(10): 381-387, 2020 05 22.
Article
en En, Es
| MEDLINE
| ID: mdl-31806387
ABSTRACT
INTRODUCTION AND OBJECTIVES:
To assess the risk factors of cytomegalovirus (CMV) infection after heart transplant (HT) and its influence on long-term prognosis.METHODS:
We conducted a retrospective single-centre study of 222 HT recipients. Risk factors for CMV infection were identified by means of multivariable CoxÌs regression. Kaplan-Meier analysis and CoxÌs regression were used to assess the long-term prognostic impact of CMV infection during the first post-transplant year.RESULTS:
Donor-recipient CMV serologic matching (hazard ratio [HR] 1.92, 95% confidence interval [95% CI] 1.2-3.09, p=.007), recipient age (HR 1.02, 95% CI 1.00-1.1, p=.02), diabetes mellitus (HR 1.86, 95% CI 1.4-3.05, p=.01), pre-transplant circulatory support (HR 1.59, 95% CI 1.06-2.38, p=.03) and the use of tacrolimus (HR 1.64, 95% CI 1.13-2.36, p=.009) were independently associated with increased risk of CMV infection. CMV infection during the first year post-HT was not associated with worse transplant outcomes in terms of mortality, incidence of heart failure, cardiac allograft vasculopathy or acute rejection.CONCLUSIONS:
CMV infection was not associated with impaired long-term prognosis after HT.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Corazón
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Infecciones por Citomegalovirus
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Idioma:
En
/
Es
Revista:
Med Clin (Barc)
Año:
2020
Tipo del documento:
Article