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Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial.
Younossi, Zobair M; Ratziu, Vlad; Loomba, Rohit; Rinella, Mary; Anstee, Quentin M; Goodman, Zachary; Bedossa, Pierre; Geier, Andreas; Beckebaum, Susanne; Newsome, Philip N; Sheridan, David; Sheikh, Muhammad Y; Trotter, James; Knapple, Whitfield; Lawitz, Eric; Abdelmalek, Manal F; Kowdley, Kris V; Montano-Loza, Aldo J; Boursier, Jerome; Mathurin, Philippe; Bugianesi, Elisabetta; Mazzella, Giuseppe; Olveira, Antonio; Cortez-Pinto, Helena; Graupera, Isabel; Orr, David; Gluud, Lise Lotte; Dufour, Jean-Francois; Shapiro, David; Campagna, Jason; Zaru, Luna; MacConell, Leigh; Shringarpure, Reshma; Harrison, Stephen; Sanyal, Arun J.
Afiliación
  • Younossi ZM; Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, USA.
  • Ratziu V; Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Institute for Cardiometabolism and Nutrition, Paris, France.
  • Loomba R; NAFLD Rsearch Center, University of California San Diego, San Diego, CA, USA.
  • Rinella M; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Anstee QM; The Newcastle Liver Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
  • Goodman Z; Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, USA.
  • Bedossa P; Service d'Anatomie Pathologique, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Geier A; Department of Hepatology, University of Wuerzburg, Wuerzburg, Germany.
  • Beckebaum S; St Josef-Krankenhaus Kupferdreh, Essen, Germany.
  • Newsome PN; National Institute for Health Research Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
  • Sheridan D; Institute of Translational & Stratified Medicine, University of Plymouth and University Hospitals Plymouth NHS Trust, Plymouth, UK.
  • Sheikh MY; Fresno Clinical Research Center, Fresno, CA, USA.
  • Trotter J; Baylor Health, Liver Consultants of Texas, Dallas, TX, USA.
  • Knapple W; Arkansas Gastroenterology, North Little Rock, AR, USA.
  • Lawitz E; Texas Liver Institute, University of Texas Health San Antonio, San Antonio, TX, USA.
  • Abdelmalek MF; Division of Gastroenterology and Hepatology, Duke University Medical Center, Durham, NC, USA.
  • Kowdley KV; Swedish Liver Center, Seattle, WA, USA.
  • Montano-Loza AJ; Division of Gastroenterology and Liver Unit, University of Alberta, Edmonton, Canada.
  • Boursier J; HIFIH Laboratory, UPRES EA3859, SFR 4208, Angers University, Angers, France; Hepato-Gastroenterology Department, Angers University Hospital, Angers, France.
  • Mathurin P; Hepato-gastroenterology, CHU Lille, Lille, France.
  • Bugianesi E; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Mazzella G; Dipartimento di Scienze Mediche e Chirurgiche, University of Bologna, Bologna, Italy.
  • Olveira A; Department of Gastroenterology, Hospital Universitario La Paz, Madrid, Spain.
  • Cortez-Pinto H; Clínica Universitária de Gastrenterologia, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
  • Graupera I; Liver Unit, Hospital Clínic de Barcelona, Barcelona, Spain; Institut D'investigacions Biomèdiques August Pi I Sunyer, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.
  • Orr D; New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealand.
  • Gluud LL; The Gastrounit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
  • Dufour JF; University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland.
  • Shapiro D; Intercept Pharmaceuticals, San Diego, CA, USA.
  • Campagna J; Intercept Pharmaceuticals, San Diego, CA, USA.
  • Zaru L; Intercept Pharmaceuticals, San Diego, CA, USA.
  • MacConell L; Intercept Pharmaceuticals, San Diego, CA, USA.
  • Shringarpure R; Intercept Pharmaceuticals, San Diego, CA, USA.
  • Harrison S; Pinnacle Clinical Research Center, San Antonio, TX, USA.
  • Sanyal AJ; Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: arun.sanyal@vcuhealth.org.
Lancet ; 394(10215): 2184-2196, 2019 12 14.
Article en En | MEDLINE | ID: mdl-31813633
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ácido Quenodesoxicólico / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Lancet Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ácido Quenodesoxicólico / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Lancet Año: 2019 Tipo del documento: Article