The emergence of Staphylococcus epidermidis simultaneously nonsusceptible to linezolid and teicoplanin in China.
Diagn Microbiol Infect Dis
; 96(2): 114956, 2020 Feb.
Article
en En
| MEDLINE
| ID: mdl-31813640
ABSTRACT
Two linezolid-resistant and teicoplanin-intermediate Staphylococcus epidermidis strains were isolated from blood cultures in China. The 2 S. epidermidis strains were methicillin-resistant and showed multidrug-resistance patterns; in addition, population analysis profiling/area under the curve (PAP/AUC) result showed heterogeneous resistant to vancomycin. Comparing to teicoplanin susceptible strains, the 2 isolates showed reduced autolytic activity. Pulsed field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) indicated that the 2 S. epidermidis isolates belonged to the same clone. Furthermore, the cfr gene, a G2576T mutation, and a novel C2146T mutation were detected in the 2 isolates. This was the first report of S. epidermidis simultaneously nonsusceptible to linezolid and teicoplanin in China.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Infecciones Estafilocócicas
/
Staphylococcus epidermidis
/
Teicoplanina
/
Enfermedades Transmisibles Emergentes
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Linezolid
/
Antibacterianos
Tipo de estudio:
Prognostic_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Diagn Microbiol Infect Dis
Año:
2020
Tipo del documento:
Article