Development of a prognostic composite cytokine signature based on the correlation with nivolumab clearance: translational PK/PD analysis in patients with renal cell carcinoma.

Wang, Rui; Zheng, Junying; Shao, Xiao; Ishii, Yuko; Roy, Amit; Bello, Akintunde; Lee, Richard; Zhang, Joshua; Wind-Rotolo, Megan; Feng, Yan

Wang, Rui; Zheng, Junying; Shao, Xiao; Ishii, Yuko; Roy, Amit; Bello, Akintunde; Lee, Richard; Zhang, Joshua; Wind-Rotolo, Megan; Feng, Yan.

Afiliación

Wang R; Bristol-Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
Zheng J; Bristol-Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
Shao X; Bristol-Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
Ishii Y; Bristol-Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
Roy A; Bristol-Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
Bello A; Bristol-Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
Lee R; Bristol-Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
Zhang J; Bristol-Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
Wind-Rotolo M; Bristol-Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
Feng Y; Bristol-Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA. Yan.Feng@bms.com.

J Immunother Cancer ; 7(1): 348, 2019 12 11.

Article en En | MEDLINE | ID: mdl-31829287

Asunto(s)

Antineoplásicos Inmunológicos/farmacología; Carcinoma de Células Renales/metabolismo; Citocinas/metabolismo; Neoplasias Renales/metabolismo; Nivolumab/farmacología; Biomarcadores; Carcinoma de Células Renales/tratamiento farmacológico; Carcinoma de Células Renales/mortalidad; Carcinoma de Células Renales/patología; Línea Celular Tumoral; Biología Computacional/métodos; Femenino; Humanos; Neoplasias Renales/tratamiento farmacológico; Neoplasias Renales/mortalidad; Neoplasias Renales/patología; Aprendizaje Automático; Masculino; Pronóstico; Reproducibilidad de los Resultados

Palabras clave

Clearance; Composite signature; Cytokine; Nivolumab; Renal cell carcinoma; Translational PK/PD analysis

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Citocinas / Antineoplásicos Inmunológicos / Nivolumab / Neoplasias Renales Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: J Immunother Cancer Año: 2019 Tipo del documento: Article

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