Age-related insult of cochlear ribbon synapses: An early-onset contributor to D-galactose-induced aging in mice.

Du, Zheng-De; Han, Shu-Guang; Qu, Teng-Fei; Guo, Bin; Yu, Shu-Kui; Wei, Wei; Feng, Shuai; Liu, Ke; Gong, Shu-Sheng

Du, Zheng-De; Han, Shu-Guang; Qu, Teng-Fei; Guo, Bin; Yu, Shu-Kui; Wei, Wei; Feng, Shuai; Liu, Ke; Gong, Shu-Sheng.

Afiliación

Du ZD; Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, China.
Han SG; Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, China.
Qu TF; Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, China.
Guo B; Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, China.
Yu SK; Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, China.
Wei W; Department of Otology, Shengjing Hospital, China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, China.
Feng S; Department of Otorhinolaryngology, The First Hospital of China Medical University, 155 Nanjingbei Street, Heping District, Shenyang, 110000, China.
Liu K; Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, China. Electronic address: keliu66@hotmail.com.
Gong SS; Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, China. Electronic address: gongss1962@163.com.

Neurochem Int ; 133: 104649, 2020 02.

Article en En | MEDLINE | ID: mdl-31870891

Asunto(s)

Envejecimiento/metabolismo; Cóclea/fisiopatología; Galactosa/farmacología; Sinapsis/metabolismo; Animales; Apoptosis/efectos de los fármacos; Apoptosis/fisiología; Cóclea/metabolismo; Modelos Animales de Enfermedad; Potenciales Evocados Auditivos del Tronco Encefálico/efectos de los fármacos; Potenciales Evocados Auditivos del Tronco Encefálico/fisiología; Peróxido de Hidrógeno/metabolismo; Peróxido de Hidrógeno/farmacología; Masculino; Ratones Endogámicos C57BL; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Sinapsis/efectos de los fármacos

Palabras clave

Cochlear ribbon synapsis; D-galactose; Mitochondria; Oxidative damage; Presbycusis

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sinapsis / Envejecimiento / Cóclea / Galactosa Tipo de estudio: Prognostic_studies Idioma: En Revista: Neurochem Int Año: 2020 Tipo del documento: Article

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