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Progress and Opportunities to Advance Clinical Cancer Therapeutics Using Tumor Dynamic Models.
Bruno, René; Bottino, Dean; de Alwis, Dinesh P; Fojo, Antonio T; Guedj, Jérémie; Liu, Chao; Swanson, Kristin R; Zheng, Jenny; Zheng, Yanan; Jin, Jin Y.
Afiliación
  • Bruno R; Genentech-Roche, Marseille, France. rene.bruno@roche.com.
  • Bottino D; Millennium Pharmaceuticals, a wholly owned subsidiary of Takeda Pharmaceuticals, Inc. Cambridge, Massachusetts.
  • de Alwis DP; Merck & Co., Inc., Kenilworth, New Jersey.
  • Fojo AT; Columbia University, New York, New York.
  • Guedj J; IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
  • Liu C; U.S. Food and Drug Administration, Silver Spring, Maryland.
  • Swanson KR; Mayo Clinic, Scottsdale, Arizona.
  • Zheng J; Pfizer, Collegeville, Pennsylvania.
  • Zheng Y; MedImmune, Mountain View, California.
  • Jin JY; Genentech-Roche, South San Francisco, California.
Clin Cancer Res ; 26(8): 1787-1795, 2020 04 15.
Article en En | MEDLINE | ID: mdl-31871299
There is a need for new approaches and endpoints in oncology drug development, particularly with the advent of immunotherapies and the multiple drug combinations under investigation. Tumor dynamics modeling, a key component to oncology "model-informed drug development," has shown a growing number of applications and a broader adoption by drug developers and regulatory agencies in the past years to support drug development and approval in a variety of ways. Tumor dynamics modeling is also being investigated in personalized cancer therapy approaches. These models and applications are reviewed and discussed, as well as the limitations and issues open for further investigations. A close collaboration between stakeholders like clinical investigators, statisticians, and pharmacometricians is warranted to advance clinical cancer therapeutics.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carga Tumoral / Inmunoterapia / Modelos Biológicos / Modelos Teóricos / Neoplasias / Antineoplásicos Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carga Tumoral / Inmunoterapia / Modelos Biológicos / Modelos Teóricos / Neoplasias / Antineoplásicos Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article