Brain imaging correlates of self- and other-reflection in schizophrenia.
Neuroimage Clin
; 25: 102134, 2020.
Article
en En
| MEDLINE
| ID: mdl-31877452
ABSTRACT
BACKGROUND:
An alteration in self/other differentiation has been proposed as a basis for several symptoms in schizophrenia, including delusions of reference and social functioning deficits. Dysfunction of the right temporo-parietal junction (TPJ), a region linked with social cognition, has been proposed as the basis of this alteration. However, imaging studies of self- and other-processing in schizophrenia have shown, so far, inconsistent results.METHODS:
Patients with schizophrenia and healthy controls underwent fMRI scanning while performing a task with three conditions self-reflection, other-reflection and semantic processing.RESULTS:
Both groups activated similar brain regions for self- and other-reflection compared to semantic processing, including the medial prefrontal cortex, the precuneus and the TPJ. Compared to healthy subjects, patients hyperactivated the left lateral frontal cortex during self- and other-reflection. In other-reflection, compared to self-reflection, patients failed to increase right TPJ activity.CONCLUSIONS:
Altered activity in the right TPJ supports a disturbance in self/other differentiation in schizophrenia, which could be linked with psychotic symptoms and affect social functioning in patients. Hyperactivity of the lateral frontal cortex for self- and other-reflection suggests the presence of greater cognitive demand to perform the task in the patient group.Palabras clave
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MEDLINE
Asunto principal:
Esquizofrenia
/
Psicología del Esquizofrénico
/
Encéfalo
Idioma:
En
Revista:
Neuroimage Clin
Año:
2020
Tipo del documento:
Article