Two folate-derived analogues from an aqueous decoction of Uncaria rhynchophylla.
Chin J Nat Med
; 17(12): 928-934, 2019 Dec.
Article
en En
| MEDLINE
| ID: mdl-31882048
ABSTRACT
Two new folate-derived analogues, named uncarophyllofolic acids A (1) and B (2), respectively, were isolated from the Uncaria rhynchophylla hook bearing stem (Gouteng in Chinese). The distinct stereochemical structures of 1 and 2 were determined by spectroscopic data analysis in combination with acidic hydrolysis and Marfey's derivatization, along with comparison of their specific rotation and Cotton effect (CE) data with those of the biogenetically related known derivatives as well as theoretical calculations of electronic circular dichroism (ECD) spectra. A plausible biosynthetic pathway of 1 and 2, associating to folate metabolism and the previously reported orychophragines A-C from Orychophragmus violaceus, is discussed.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Uncaria
/
Ácido Fólico
País/Región como asunto:
Asia
Idioma:
En
Revista:
Chin J Nat Med
Año:
2019
Tipo del documento:
Article