The Effect of Liver Hydrolysate on Chronic Ethanol-Induced Hepatic Injury in Normal Rats.
Biol Pharm Bull
; 43(3): 554-557, 2020 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-31915312
ABSTRACT
The mechanism underlying the improvement in hepatic function by liver hydrolysate (LH) after ethanol-induced hepatic injury is unclear. Therefore, we investigated the effects of LH administration on chronic ethanol-induced hepatic injury in normal rats and the mechanism underlying the improvement of its symptoms by LH. LH attenuated liver damage and reduced oxidative stress after chronic ethanol-induced hepatic injury in normal rats. LH treatment reduced hepatic injury biomarkers of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). LH treatment also decreased levels of 8-hydroxy-deoxyguanosine (8-OHdG) as oxidative stress marker. LH may prove beneficial to prevent the liver damage of chronic ethanol, at least in part, by alleviating oxidative stress.
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Base de datos:
MEDLINE
Asunto principal:
Etanol
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Hígado
Idioma:
En
Revista:
Biol Pharm Bull
Asunto de la revista:
BIOQUIMICA
/
FARMACOLOGIA
Año:
2020
Tipo del documento:
Article