Libertellenone M, a diterpene derived from an endophytic fungus Phomopsis sp. S12, protects against DSS-induced colitis via inhibiting both nuclear translocation of NF-&#954;B and NLRP3 inflammasome activation.

Fan, Minmin; Xiang, Gang; Chen, Jingwei; Gao, Jian; Xue, Wenwen; Wang, Yixuan; Li, Wuhao; Zhou, Lin; Jiao, Ruihua; Shen, Yan; Xu, Qiang

Libertellenone M, a diterpene derived from an endophytic fungus Phomopsis sp. S12, protects against DSS-induced colitis via inhibiting both nuclear translocation of NF-κB and NLRP3 inflammasome activation.

Fan, Minmin; Xiang, Gang; Chen, Jingwei; Gao, Jian; Xue, Wenwen; Wang, Yixuan; Li, Wuhao; Zhou, Lin; Jiao, Ruihua; Shen, Yan; Xu, Qiang.

Afiliación

Fan M; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
Xiang G; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
Chen J; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
Gao J; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
Xue W; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
Wang Y; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
Li W; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
Zhou L; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
Jiao R; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
Shen Y; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China. Electronic address: shenyan@nju.edu.cn.
Xu Q; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China. Electronic address: molpharm@163.com.

Int Immunopharmacol ; 80: 106144, 2020 Mar.

Article en En | MEDLINE | ID: mdl-31927507

Asunto(s)

Antiinflamatorios/uso terapéutico; Colitis/tratamiento farmacológico; Diterpenos/uso terapéutico; Inflamasomas/antagonistas & inhibidores; Proteína con Dominio Pirina 3 de la Familia NLR/antagonistas & inhibidores; Factor de Transcripción ReIA/antagonistas & inhibidores; Animales; Antiinflamatorios/farmacología; Ascomicetos; Colitis/inducido químicamente; Colitis/inmunología; Colitis/patología; Colon/efectos de los fármacos; Colon/inmunología; Colon/patología; Citocinas/genética; Citocinas/inmunología; Sulfato de Dextran; Diterpenos/farmacología; Femenino; Inflamasomas/inmunología; Ratones; Ratones Endogámicos C57BL; Proteína con Dominio Pirina 3 de la Familia NLR/inmunología; Células RAW 264.7; Factor de Transcripción ReIA/inmunología

Palabras clave

Anti-inflammatory; Endophytic fungus; Experimental colitis; Libertellenone M; NLRP3 inflammasome

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Colitis / Diterpenos / Factor de Transcripción ReIA / Inflamasomas / Proteína con Dominio Pirina 3 de la Familia NLR / Antiinflamatorios Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2020 Tipo del documento: Article

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