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First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma.
Wen, Patrick Y; Cloughesy, Timothy F; Olivero, Alan G; Morrissey, Kari M; Wilson, Timothy R; Lu, Xuyang; Mueller, Lars U; Coimbra, Alexandre F; Ellingson, Benjamin M; Gerstner, Elizabeth; Lee, Eudocia Q; Rodon, Jordi.
Afiliación
  • Wen PY; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. pwen@partners.org.
  • Cloughesy TF; Department of Neurology, Ronald Reagan UCLA Medical Center, University of California Los Angeles, Los Angeles, California.
  • Olivero AG; Genentech, Inc., South San Francisco, California.
  • Morrissey KM; Genentech, Inc., South San Francisco, California.
  • Wilson TR; Genentech, Inc., South San Francisco, California.
  • Lu X; Genentech, Inc., South San Francisco, California.
  • Mueller LU; Genentech, Inc., South San Francisco, California.
  • Coimbra AF; Genentech, Inc., South San Francisco, California.
  • Ellingson BM; UCLA Brain Tumor Imaging Laboratory, Center for Computer Vision and Imaging Biomarkers, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
  • Gerstner E; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.
  • Lee EQ; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Rodon J; Vall d'Hebron Institute of Oncology, Barcelona, Spain.
Clin Cancer Res ; 26(8): 1820-1828, 2020 04 15.
Article en En | MEDLINE | ID: mdl-31937616
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Oxazinas / Pirimidinas / Encéfalo / Fosfatidilinositol 3-Quinasas / Serina-Treonina Quinasas TOR / Glioma / Recurrencia Local de Neoplasia Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Oxazinas / Pirimidinas / Encéfalo / Fosfatidilinositol 3-Quinasas / Serina-Treonina Quinasas TOR / Glioma / Recurrencia Local de Neoplasia Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article