Tetradeca-thiolated cyclodextrins: Highly mucoadhesive and in-situ gelling oligomers with prolonged mucosal adhesion.

Hussain Asim, Mulazim; Nazir, Imran; Jalil, Aamir; Matuszczak, Barbara; Bernkop-Schnürch, Andreas

Hussain Asim, Mulazim; Nazir, Imran; Jalil, Aamir; Matuszczak, Barbara; Bernkop-Schnürch, Andreas.

Afiliación

Hussain Asim M; Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria; Department of Pharmaceutics, Faculty of Pharmacy, University of Sargodha, 40100 Sargodha, Pakistan.
Nazir I; Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria; Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan.
Jalil A; Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Matuszczak B; Center for Chemistry and Biomedicine, Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Bernkop-Schnürch A; Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address: andreas.bernkop@uibk.ac.at.

Int J Pharm ; 577: 119040, 2020 Mar 15.

Article en En | MEDLINE | ID: mdl-31953091

Asunto(s)

Sistemas de Liberación de Medicamentos; Moco/metabolismo; beta-Ciclodextrinas/química; Adhesividad; Animales; Células CACO-2; Femenino; Geles; Humanos; Concentración de Iones de Hidrógeno; Oxidación-Reducción; Compuestos de Sulfhidrilo/química; Porcinos; beta-Ciclodextrinas/síntesis química; beta-Ciclodextrinas/metabolismo

Palabras clave

Cyclodextrins; In-situ gelling; Microwave-assisted thiolated cyclodextrin; Mucoadhesion; Tetradeca-thiolated cyclodextrin; Thiolated; Thiolated cyclodextrin; Thiomers; ß-Cyclodextrin

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Beta-Ciclodextrinas / Moco Idioma: En Revista: Int J Pharm Año: 2020 Tipo del documento: Article

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