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Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.
Craig, Jamie E; Han, Xikun; Qassim, Ayub; Hassall, Mark; Cooke Bailey, Jessica N; Kinzy, Tyler G; Khawaja, Anthony P; An, Jiyuan; Marshall, Henry; Gharahkhani, Puya; Igo, Robert P; Graham, Stuart L; Healey, Paul R; Ong, Jue-Sheng; Zhou, Tiger; Siggs, Owen; Law, Matthew H; Souzeau, Emmanuelle; Ridge, Bronwyn; Hysi, Pirro G; Burdon, Kathryn P; Mills, Richard A; Landers, John; Ruddle, Jonathan B; Agar, Ashish; Galanopoulos, Anna; White, Andrew J R; Willoughby, Colin E; Andrew, Nicholas H; Best, Stephen; Vincent, Andrea L; Goldberg, Ivan; Radford-Smith, Graham; Martin, Nicholas G; Montgomery, Grant W; Vitart, Veronique; Hoehn, Rene; Wojciechowski, Robert; Jonas, Jost B; Aung, Tin; Pasquale, Louis R; Cree, Angela Jane; Sivaprasad, Sobha; Vallabh, Neeru A; Viswanathan, Ananth C; Pasutto, Francesca; Haines, Jonathan L; Klaver, Caroline C W; van Duijn, Cornelia M; Casson, Robert J.
Afiliación
  • Craig JE; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
  • Han X; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Xikun.Han@qimrberghofer.edu.au.
  • Qassim A; School of Medicine, University of Queensland, Brisbane, Queensland, Australia. Xikun.Han@qimrberghofer.edu.au.
  • Hassall M; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
  • Cooke Bailey JN; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
  • Kinzy TG; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Khawaja AP; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • An J; National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
  • Marshall H; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Gharahkhani P; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
  • Igo RP; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Graham SL; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Healey PR; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
  • Ong JS; Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
  • Zhou T; Clinical Ophthalmology & Eye Health, Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia.
  • Siggs O; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Law MH; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
  • Souzeau E; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
  • Ridge B; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Hysi PG; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
  • Burdon KP; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
  • Mills RA; Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK.
  • Landers J; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
  • Ruddle JB; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
  • Agar A; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
  • Galanopoulos A; Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.
  • White AJR; Department of Ophthalmology, Prince of Wales Hospital Randwick, Sydney, New South Wales, Australia.
  • Willoughby CE; South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
  • Andrew NH; Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
  • Best S; Clinical Ophthalmology & Eye Health, Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia.
  • Vincent AL; Biomedical Sciences Research Institute, Ulster University, Coleraine, UK.
  • Goldberg I; Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, UK.
  • Radford-Smith G; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
  • Martin NG; Eye Department, Greenlane Clinical Centre, Auckland District Health Board, Auckland, New Zealand.
  • Montgomery GW; Department of Ophthalmology, University of Auckland, Auckland, New Zealand.
  • Vitart V; Discipline of Ophthalmology, Faculty of Medicine and Health, University of Sydney, Sydney Eye Hospital, Sydney, New South Wales, Australia.
  • Hoehn R; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Wojciechowski R; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Jonas JB; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  • Aung T; Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Pasquale LR; Department of Ophthalmology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
  • Cree AJ; Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.
  • Sivaprasad S; Department of Epidemiology and Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Vallabh NA; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Viswanathan AC; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Pasutto F; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Haines JL; National Institute for Health Research Moorfields Biomedical Research Centre, London, UK.
  • Klaver CCW; Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
  • van Duijn CM; St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.
Nat Genet ; 52(2): 160-166, 2020 02.
Article en En | MEDLINE | ID: mdl-31959993
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Glaucoma / Polimorfismo de Nucleótido Simple Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies País/Región como asunto: America do norte / Europa / Oceania Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2020 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Glaucoma / Polimorfismo de Nucleótido Simple Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies País/Región como asunto: America do norte / Europa / Oceania Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2020 Tipo del documento: Article