Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity.

Zhou, Xinzhu; St Pierre, Celine L; Gonzales, Natalia M; Zou, Jennifer; Cheng, Riyan; Chitre, Apurva S; Sokoloff, Greta; Palmer, Abraham A

Zhou, Xinzhu; St Pierre, Celine L; Gonzales, Natalia M; Zou, Jennifer; Cheng, Riyan; Chitre, Apurva S; Sokoloff, Greta; Palmer, Abraham A.

Afiliación

Zhou X; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, 92092.
St Pierre CL; Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63110.
Gonzales NM; Department of Human Genetics, University of Chicago, IL, 60637.
Zou J; Department of Computer Science, University of California, Los Angeles, CA, 90095.
Cheng R; Department of Psychiatry.
Chitre AS; Department of Psychiatry.
Sokoloff G; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IO, 52242.
Palmer AA; Department of Psychiatry, aap@ucsd.edu.

G3 (Bethesda) ; 10(3): 951-965, 2020 03 05.

Article en En | MEDLINE | ID: mdl-31974095

Asunto(s)

Cruzamientos Genéticos; Estudio de Asociación del Genoma Completo; Pelaje de Animal; Animales; Peso Corporal; Color; Femenino; Genotipo; Locomoción/efectos de los fármacos; Masculino; Metanfetamina/farmacología; Ratones Endogámicos; Fenotipo; Polimorfismo de Nucleótido Simple; Reproducibilidad de los Resultados

Palabras clave

GWAS; MPP; Mouse Genetics; Multiparent Advanced Generation Inter-Cross (MAGIC); Replication; multiparental; populations

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cruzamientos Genéticos / Estudio de Asociación del Genoma Completo Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: G3 (Bethesda) Año: 2020 Tipo del documento: Article

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