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Morindolestatin, Naturally Occurring Dehydromorpholinocarbazole Alkaloid from Soil-Derived Bacterium of the Genus Streptomyces.
Zhang, Shao-Yong; Zhan, Zha-Jun; Zhang, Hui; Qi, Huan; Zhang, Li-Qin; Chen, Shi-Xin; Gan, Li-She; Wang, Ji-Dong; Ma, Lie-Feng.
Afiliación
  • Zhang SY; College of Life Science, Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province , Huzhou University , Huzhou 313000 , P.R. China.
  • Zhan ZJ; College of Pharmaceutical Science , Zhejiang University of Technology , Hangzhou 310014 , P.R. China.
  • Zhang H; Zhejiang Key Laboratory of Antifungal Drugs , Zhejiang Hisun Pharmaceutical Co., Ltd. , Taizhou 318000 , P.R. China.
  • Qi H; College of Life Science, Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province , Huzhou University , Huzhou 313000 , P.R. China.
  • Zhang LQ; College of Life Science, Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province , Huzhou University , Huzhou 313000 , P.R. China.
  • Chen SX; Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences , Zhejiang University , Hangzhou 310058 , P.R. China.
  • Gan LS; Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences , Zhejiang University , Hangzhou 310058 , P.R. China.
  • Wang JD; College of Life Science, Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province , Huzhou University , Huzhou 313000 , P.R. China.
  • Ma LF; College of Pharmaceutical Science , Zhejiang University of Technology , Hangzhou 310014 , P.R. China.
Org Lett ; 22(3): 1113-1116, 2020 02 07.
Article en En | MEDLINE | ID: mdl-31977234
ABSTRACT
Novel antilipid peroxidative carbazole alkaloids, antiostatin A5 (1), antiostatin A6 (2), and (±)-morindolestatin (3), were isolated from a new soil-derived Streptomyces sp. Compound 2 possesses an unusual cyclohexene side chain. Compound 3 was a pair of enantiomers featuring an unprecedented [1,4]oxazino[2,3-c]carbazole ring system. The absolute configuration of 3 was determined by online HPLC-ECD and ECD calculation. A racemization mechanism and putative biosynthetic pathway are discussed.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Streptomyces / Productos Biológicos / Carbazoles / Alcaloides Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Streptomyces / Productos Biológicos / Carbazoles / Alcaloides Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article