Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer's Diseases.

Guo, Yan; Yang, Hongyu; Huang, Zhongwei; Tian, Sen; Li, Qihang; Du, Chenxi; Chen, Tingkai; Liu, Yang; Sun, Haopeng; Liu, Zongliang

Guo, Yan; Yang, Hongyu; Huang, Zhongwei; Tian, Sen; Li, Qihang; Du, Chenxi; Chen, Tingkai; Liu, Yang; Sun, Haopeng; Liu, Zongliang.

Afiliación

Guo Y; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China.
Yang H; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Huang Z; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China.
Tian S; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China.
Li Q; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Du C; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Chen T; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Liu Y; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Sun H; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Liu Z; Jiangsu Food and Pharmaceutical Science College, Huaian 223003, China.

Molecules ; 25(3)2020 Jan 23.

Article en En | MEDLINE | ID: mdl-31979317

Asunto(s)

Acetilcolinesterasa/química; Enfermedad de Alzheimer/enzimología; Butirilcolinesterasa/química; Inhibidores de la Colinesterasa/química; Inhibidores de la Colinesterasa/farmacología; Fármacos Neuroprotectores/farmacología; Acetilcolinesterasa/metabolismo; Enfermedad de Alzheimer/tratamiento farmacológico; Animales; Sitios de Unión; Butirilcolinesterasa/metabolismo; Dominio Catalítico; Supervivencia Celular/efectos de los fármacos; Inhibidores de la Colinesterasa/síntesis química; Donepezilo/farmacología; Cinética; Simulación del Acoplamiento Molecular; Células PC12; Ratas; Relación Estructura-Actividad; Tacrina/farmacología

Palabras clave

Alzheimer's disease; acetylcholinesterase inhibitor; butyrylcholinesterase inhibitor; cytotoxicity; molecular docking; structural modification; structure-activity relationship

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Acetilcolinesterasa / Butirilcolinesterasa / Inhibidores de la Colinesterasa / Fármacos Neuroprotectores / Enfermedad de Alzheimer Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article

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