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A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo.
Nakamori, Masayuki; Panigrahi, Gagan B; Lanni, Stella; Gall-Duncan, Terence; Hayakawa, Hideki; Tanaka, Hana; Luo, Jennifer; Otabe, Takahiro; Li, Jinxing; Sakata, Akihiro; Caron, Marie-Christine; Joshi, Niraj; Prasolava, Tanya; Chiang, Karen; Masson, Jean-Yves; Wold, Marc S; Wang, Xiaoxiao; Lee, Marietta Y W T; Huddleston, John; Munson, Katherine M; Davidson, Scott; Layeghifard, Mehdi; Edward, Lisa-Monique; Gallon, Richard; Santibanez-Koref, Mauro; Murata, Asako; Takahashi, Masanori P; Eichler, Evan E; Shlien, Adam; Nakatani, Kazuhiko; Mochizuki, Hideki; Pearson, Christopher E.
Afiliación
  • Nakamori M; Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Panigrahi GB; Program of Genetics & Genome Biology, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
  • Lanni S; Program of Genetics & Genome Biology, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
  • Gall-Duncan T; Program of Genetics & Genome Biology, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
  • Hayakawa H; Program of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Tanaka H; Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Luo J; Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Otabe T; Program of Genetics & Genome Biology, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
  • Li J; Program of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Sakata A; Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
  • Caron MC; Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
  • Joshi N; Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
  • Prasolava T; Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Quebec, Quebec, Canada.
  • Chiang K; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Quebec, Quebec, Canada.
  • Masson JY; Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Quebec, Quebec, Canada.
  • Wold MS; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Quebec, Quebec, Canada.
  • Wang X; Program of Genetics & Genome Biology, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
  • Lee MYWT; Program of Genetics & Genome Biology, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
  • Huddleston J; Program of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Munson KM; Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Quebec, Quebec, Canada.
  • Davidson S; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Quebec, Quebec, Canada.
  • Layeghifard M; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
  • Edward LM; Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY, USA.
  • Gallon R; Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY, USA.
  • Santibanez-Koref M; Department of Genome Sciences, University of Washington, Seattle, WA, USA.
  • Murata A; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
  • Takahashi MP; Department of Genome Sciences, University of Washington, Seattle, WA, USA.
  • Eichler EE; Program of Genetics & Genome Biology, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
  • Shlien A; Program of Genetics & Genome Biology, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
  • Nakatani K; Program of Genetics & Genome Biology, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
  • Mochizuki H; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
  • Pearson CE; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Nat Genet ; 52(2): 146-159, 2020 02.
Article en En | MEDLINE | ID: mdl-32060489
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Huntington / Quinolonas / Expansión de Repetición de Trinucleótido / Proteína Huntingtina / Naftiridinas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Huntington / Quinolonas / Expansión de Repetición de Trinucleótido / Proteína Huntingtina / Naftiridinas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2020 Tipo del documento: Article