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Notch1-Nrf2 signaling crosstalk provides myocardial protection by reducing ROS formation.
Zhou, Xue-Liang; Wu, Xia; Zhu, Rong-Rong; Xu, Hua; Li, Yun-Yun; Xu, Qi-Rong; Liu, Sheng; Lai, Song-Qing; Xu, Xinping; Wan, Li; Wu, Qi-Cai; Liu, Ji-Chun.
Afiliación
  • Zhou XL; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Wu X; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Zhu RR; Department of Obstetrics and Gynecology, Jiangxi Province hospital of integrated traditional Chinese and Western medicine, Nanchang, China.
  • Xu H; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Li YY; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Xu QR; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Liu S; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Lai SQ; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Xu X; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Wan L; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Wu QC; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Liu JC; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
Biochem Cell Biol ; 98(2): 106-111, 2020 04.
Article en En | MEDLINE | ID: mdl-32069075
ABSTRACT
Both the Notch1 and Keap1-Nrf2 signaling pathways have cardioprotective effects, but the role of Notch1-Nrf2 crosstalk in myocardial ischemia-reperfusion injury is unclear. In this study, we established hypoxia-reoxygenation in neonate rat myocardial cells and employed γ-secretase inhibitor and curcumin to inhibit and activate the Notch1 and Keap1-Nrf2 signaling pathways, respectively. We found that the combined action of the Notch1 and Keap1-Nrf2 signaling pathways significantly increased cardiomyocyte viability, inhibited cardiomyocyte apoptosis, reduced the formation of reactive oxygen species, and increased antioxidant activities. In conclusion, these findings suggest that Notch1-Nrf2 crosstalk exerts myocardial protection by reducing the formation of reactive oxygen species.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Miocárdica / Especies Reactivas de Oxígeno / Isquemia Miocárdica / Factor 2 Relacionado con NF-E2 / Receptor Notch1 / Proteína 1 Asociada A ECH Tipo Kelch Idioma: En Revista: Biochem Cell Biol Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Miocárdica / Especies Reactivas de Oxígeno / Isquemia Miocárdica / Factor 2 Relacionado con NF-E2 / Receptor Notch1 / Proteína 1 Asociada A ECH Tipo Kelch Idioma: En Revista: Biochem Cell Biol Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article