Vitamin D Receptor Overexpression in ß-Cells Ameliorates Diabetes in Mice.
Diabetes
; 69(5): 927-939, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-32086292
ABSTRACT
Vitamin D deficiency has been associated with increased incidence of diabetes, both in humans and in animal models. In addition, an association between vitamin D receptor (VDR) gene polymorphisms and diabetes has also been described. However, the involvement of VDR in the development of diabetes, specifically in pancreatic ß-cells, has not been elucidated yet. Here, we aimed to study the role of VDR in ß-cells in the pathophysiology of diabetes. Our results indicate that Vdr expression was modulated by glucose in healthy islets and decreased in islets from both type 1 diabetes and type 2 diabetes mouse models. In addition, transgenic mice overexpressing VDR in ß-cells were protected against streptozotocin-induced diabetes and presented a preserved ß-cell mass and a reduction in islet inflammation. Altogether, these results suggest that sustained VDR levels in ß-cells may preserve ß-cell mass and ß-cell function and protect against diabetes.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Factor II del Crecimiento Similar a la Insulina
/
Receptores de Calcitriol
/
Células Secretoras de Insulina
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Diabetes
Año:
2020
Tipo del documento:
Article