Synthesis and characterization of high affinity fluorogenic α-synuclein probes.
Chem Commun (Camb)
; 56(24): 3567-3570, 2020 Mar 24.
Article
en En
| MEDLINE
| ID: mdl-32104795
ABSTRACT
Fluorescent small molecules are powerful tools for imaging α-synuclein pathology in vitro and in vivo. In this work, we explore benzofuranone as a potential scaffold for the design of fluorescent α-synuclein probes. These compounds have high affinity for α-synuclein, show fluorescent turn-on upon binding to fibrils, and display different binding to Lewy bodies, Lewy neurites and glial cytoplasmic inclusion pathologies in post-mortem brain tissue. These studies not only reveal the potential of benzofuranone compounds as α-synuclein specific fluorescent probes, but also have implications for the ways in which α-synucleinopathies are conformationally different and display distinct small molecule binding sites.
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1
Base de datos:
MEDLINE
Asunto principal:
Benzofuranos
/
Alfa-Sinucleína
/
Colorantes Fluorescentes
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2020
Tipo del documento:
Article