Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later.
BMJ Open Diabetes Res Care
; 8(1)2020 02.
Article
en En
| MEDLINE
| ID: mdl-32107263
ABSTRACT
OBJECTIVE:
To identify the factors associated with residual C peptide production at least 10 years after diagnosis in children and adolescents with type 1 diabetes. RESEARCH DESIGN ANDMETHODS:
73 children and adolescents (<25 years), born in 1988-2005, diagnosed with type 1 diabetes were included during the 4-year study period (2013-2016). At least 10 years after diagnosis, we measured any remaining C peptide concentration using an ultrasensitive C peptide ELISA (≥1.17 pmol/L). The average hemoglobin A1c (HbA1c) was calculated during each of the 10 years after diagnosis and further grand average was calculated for the entire study period.RESULTS:
C peptide was detectable in 38% of participants. The C peptide concentration was 4.3±5.3 pmol/L. At onset of type 1 diabetes, participants were on average approximately 5 years of age, and their average HbA1c was 9.4% (79 mmol/mol). During the first 3 years after diagnosis, HbA1c was lower in the group with detectable C peptide at follow-up ≥10 years later. Moreover, detectable C peptide was more common among female participants. Body mass index SD scores had not increased since the 1-year follow-up, but were higher in patients with measurable C peptide. Nine participants (12%) had been diagnosed with celiac disease and two (3%) with hypothyreosis. Eighteen (25%) participants had retinopathy.CONCLUSIONS:
Children and adolescents with detectable C peptide after more than 10 years of diabetes duration were predominantly female and had better HbA1c than others during the first 3 years after diagnosis.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Péptido C
/
Hemoglobina Glucada
/
Sistema de Registros
/
Diabetes Mellitus Tipo 1
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
BMJ Open Diabetes Res Care
Año:
2020
Tipo del documento:
Article