Current and Future Outlook on Disease Modification and Defining Low Disease Activity in Systemic Sclerosis.
Arthritis Rheumatol
; 72(7): 1049-1058, 2020 07.
Article
en En
| MEDLINE
| ID: mdl-32134199
ABSTRACT
Systemic sclerosis (SSc) is an autoimmune rheumatic disease with heterogeneous clinical manifestations and a variable course in which the severity of the pathology dictates the disease prognosis and course. Among autoimmune rheumatic diseases, SSc has the highest mortality rate among all rheumatic diseases, though there are exciting new therapeutic targets that appear to halt the progression of SSc manifestations such as skin or lung fibrosis. In selected patients, high-intensity regimens with autologous stem cell transplantation can favorably modify the course. In what was once thought to be an untreatable disease, targeted therapies have now changed the outlook of SSc to a treatable disorder. Herein, we discuss the targeted therapies modifying the outlook on selected organ involvement and creating opportunities for future treatment. We also present a framework for defining low disease activity in SSc.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Raynaud
/
Esclerodermia Sistémica
/
Úlcera Cutánea
/
Enfermedades Pulmonares Intersticiales
/
Hipertensión Arterial Pulmonar
/
Cardiopatías
/
Enfermedades Renales
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Idioma:
En
Revista:
Arthritis Rheumatol
Año:
2020
Tipo del documento:
Article