Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms.
Molecules
; 25(5)2020 Mar 04.
Article
en En
| MEDLINE
| ID: mdl-32143423
ABSTRACT
Human induced pluripotent stem cells (hiPSCs) have transformed conventional drug discovery pathways in recent years. In particular, recent advances in hiPSC biology, including organoid technologies, have highlighted a new potential for neural drug discovery with clear advantages over the use of primary tissues. This is important considering the financial and social burden of neurological health care worldwide, directly impacting the life expectancy of many populations. Patient-derived iPSCs-neurons are invaluable tools for novel drug-screening and precision medicine approaches directly aimed at reducing the burden imposed by the increasing prevalence of neurological disorders in an aging population. 3-Dimensional self-assembled or so-called 'organoid' hiPSCs cultures offer key advantages over traditional 2D ones and may well be gamechangers in the drug-discovery quest for neurological disorders in the coming years.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Descubrimiento de Drogas
/
Células Madre Pluripotentes Inducidas
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2020
Tipo del documento:
Article