Human placenta derived mesenchymal stromal cells alleviate GVHD by promoting the generation of GSH and GST in PD-1<sup>+</sup>T cells.

Zhuoya, Wang; Nannan, Zhao; Aiping, Zhang; Guoyan, Wang; Menghua, Dong; Jiashen, Zhang; Yanlian, Xiong; Xiying, Luan

Human placenta derived mesenchymal stromal cells alleviate GVHD by promoting the generation of GSH and GST in PD-1⁺T cells.

Zhuoya, Wang; Nannan, Zhao; Aiping, Zhang; Guoyan, Wang; Menghua, Dong; Jiashen, Zhang; Yanlian, Xiong; Xiying, Luan.

Afiliación

Zhuoya W; Department of Immunology, Binzhou Medical University, Yantai, Shandong Province 264003, People's Republic of China.
Nannan Z; Department of Immunology, Binzhou Medical University, Yantai, Shandong Province 264003, People's Republic of China.
Aiping Z; Department of Immunology, Binzhou Medical University, Yantai, Shandong Province 264003, People's Republic of China.
Guoyan W; Department of Laboratory, Affiliated Yantai Hospital of Binzhou Medical University, Yantai, Shandong Province 264003, People's Republic of China.
Menghua D; Department of Pathology, Binzhou Medical University, Yantai, Shandong Province 264003, People's Republic of China.
Jiashen Z; Department of Immunology, Binzhou Medical University, Yantai, Shandong Province 264003, People's Republic of China.
Yanlian X; Department of Anatomy, Binzhou Medical University, Yantai, Shandong Province 264003, People's Republic of China. Electronic address: xyl8807@sina.com.
Xiying L; Department of Immunology, Binzhou Medical University, Yantai, Shandong Province 264003, People's Republic of China. Electronic address: xyluan@sohu.com.

Cell Immunol ; 352: 104083, 2020 06.

Article en En | MEDLINE | ID: mdl-32143837

Asunto(s)

Enfermedad Injerto contra Huésped/metabolismo; Células Madre Mesenquimatosas/metabolismo; Adulto; Animales; Diferenciación Celular/efectos de los fármacos; Células Cultivadas; China; Femenino; Citometría de Flujo; Glutatión/metabolismo; Glutatión Transferasa/metabolismo; Enfermedad Injerto contra Huésped/fisiopatología; Humanos; Interferón gamma/metabolismo; Interleucina-10/metabolismo; Células Madre Mesenquimatosas/fisiología; Ratones; Ratones Endogámicos BALB C; Ratones Endogámicos C57BL; Placenta/metabolismo; Embarazo; Receptor de Muerte Celular Programada 1/metabolismo; Linfocitos T/metabolismo

Palabras clave

Glutathione (GSH); Glutathione S transferase (GST); Graft-versus-host disease (GVHD); Mesenchymal stromal cells (MSCs); Programmed death-1 (PD-1); Reactive oxygen species (ROS)

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Células Madre Mesenquimatosas / Enfermedad Injerto contra Huésped Tipo de estudio: Prognostic_studies País/Región como asunto: Asia Idioma: En Revista: Cell Immunol Año: 2020 Tipo del documento: Article

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