Artificial intelligence and radiomics enhance the positive predictive value of digital chest tomosynthesis for lung cancer detection within SOS clinical trial.
Eur Radiol
; 30(7): 4134-4140, 2020 Jul.
Article
en En
| MEDLINE
| ID: mdl-32166491
ABSTRACT
OBJECTIVE:
To enhance the positive predictive value (PPV) of chest digital tomosynthesis (DTS) in the lung cancer detection with the analysis of radiomics features.METHOD:
The investigation was carried out within the SOS clinical trial (NCT03645018) for lung cancer screening with DTS. Lung nodules were identified by visual analysis and then classified using the diameter and the radiological aspect of the nodule following lung-RADS. Haralick texture features were extracted from the segmented nodules. Both semantic variables and radiomics features were used to build a predictive model using logistic regression on a subset of variables selected with backward feature selection and using two machine learning a Random Forest and a neural network with the whole subset of variables. The methods were applied to a train set and validated on a test set where diagnostic accuracy metrics were calculated.RESULTS:
Binary visual analysis had a good sensitivity (0.95) but a low PPV (0.14). Lung-RADS classification increased the PPV (0.19) but with an unacceptable low sensitivity (0.65). Logistic regression showed a mildly increased PPV (0.29) but a lower sensitivity (0.20). Random Forest demonstrated a moderate PPV (0.40) but with a low sensitivity (0.30). Neural network demonstrated to be the best predictor with a high PPV (0.95) and a high sensitivity (0.90).CONCLUSIONS:
The neural network demonstrated the best PPV. The use of visual analysis along with neural network could help radiologists to reduce the number of false positive in DTS. KEY POINTS ⢠We investigated several approaches to enhance the positive predictive value of chest digital tomosynthesis in the lung cancer detection. ⢠Neural network demonstrated to be the best predictor with a nearly perfect PPV. ⢠Neural network could help radiologists to reduce the number of false positive in DTS.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Procesamiento de Imagen Asistido por Computador
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Inteligencia Artificial
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Tomografía Computarizada por Rayos X
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Neoplasias Pulmonares
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Idioma:
En
Revista:
Eur Radiol
Asunto de la revista:
RADIOLOGIA
Año:
2020
Tipo del documento:
Article