Culture on a native bone marrow-derived extracellular matrix restores the pancreatic islet basement membrane, preserves islet function, and attenuates islet immunogenicity.

Wang, Hanzhou; Li, Shengxian; Dai, Qiuxia; Gonzalez, Aaron; Tran, Olivia N; Sun, Haiyan; DeFronzo, Ralph A; Dean, David D; Yeh, Chih-Ko; Chen, Xiao-Dong

Wang, Hanzhou; Li, Shengxian; Dai, Qiuxia; Gonzalez, Aaron; Tran, Olivia N; Sun, Haiyan; DeFronzo, Ralph A; Dean, David D; Yeh, Chih-Ko; Chen, Xiao-Dong.

Afiliación

Wang H; Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Li S; Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Dai Q; Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Gonzalez A; Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Tran ON; Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Sun H; Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, TX, USA.
DeFronzo RA; Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Dean DD; Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, TX, USA.
Yeh CK; Department of Stomatology, Affiliated Hospital of the Academy of Military Medical Sciences, Beijing, People's Republic of China.
Chen XD; Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

FASEB J ; 34(6): 8044-8056, 2020 06.

Article en En | MEDLINE | ID: mdl-32307751

Asunto(s)

Membrana Basal/fisiología; Médula Ósea/fisiología; Matriz Extracelular/fisiología; Tolerancia Inmunológica/fisiología; Islotes Pancreáticos/inmunología; Islotes Pancreáticos/fisiología; Animales; Membrana Basal/inmunología; Membrana Basal/metabolismo; Médula Ósea/inmunología; Médula Ósea/metabolismo; Colágeno Tipo VI/inmunología; Colágeno Tipo VI/metabolismo; Matriz Extracelular/inmunología; Matriz Extracelular/metabolismo; Fibronectinas/inmunología; Fibronectinas/metabolismo; Glucosa/inmunología; Glucosa/metabolismo; Tolerancia Inmunológica/inmunología; Insulina/inmunología; Insulina/metabolismo; Secreción de Insulina/inmunología; Secreción de Insulina/fisiología; Islotes Pancreáticos/metabolismo; Trasplante de Islotes Pancreáticos/métodos; Masculino; Ratas; Ratas Endogámicas F344; Ratas Endogámicas Lew; Ratas Endogámicas WF

Palabras clave

extracellular matrix; immune tolerance; insulin secretion; pancreatic islets; vascular endothelial cells

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Membrana Basal / Médula Ósea / Islotes Pancreáticos / Matriz Extracelular / Tolerancia Inmunológica Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2020 Tipo del documento: Article

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