Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo[2,1-f][1,2,4]triazine derivatives.

Xiang, Hao-Yue; Chen, Yan-Hong; Wang, Yi; Zhang, Xi; Ding, Jian; Meng, Ling-Hua; Yang, Chun-Hao

Xiang, Hao-Yue; Chen, Yan-Hong; Wang, Yi; Zhang, Xi; Ding, Jian; Meng, Ling-Hua; Yang, Chun-Hao.

Afiliación

Xiang HY; College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.
Chen YH; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.
Wang Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.
Zhang X; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.
Ding J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.
Meng LH; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China. Electronic address: lhmeng@simm.ac.cn.
Yang CH; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China. Electronic address: chyang@simm.ac.cn.

Bioorg Med Chem Lett ; 30(12): 127194, 2020 06 15.

Article en En | MEDLINE | ID: mdl-32317209

Asunto(s)

Antineoplásicos/farmacología; Diseño de Fármacos; Inhibidores de Proteínas Quinasas/farmacología; Triazinas/farmacología; Antineoplásicos/síntesis química; Antineoplásicos/química; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Fosfatidilinositol 3-Quinasa Clase I/antagonistas & inhibidores; Fosfatidilinositol 3-Quinasa Clase I/metabolismo; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Estructura Molecular; Inhibidores de Proteínas Quinasas/síntesis química; Inhibidores de Proteínas Quinasas/química; Relación Estructura-Actividad; Triazinas/síntesis química; Triazinas/química

Palabras clave

Antiproliferative; Cancer; Kinase; PI3K inhibitors; Pyrrolo[2,1-f][1,2,4]triazine; Therapy

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Triazinas / Diseño de Fármacos / Inhibidores de Proteínas Quinasas / Antineoplásicos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article

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