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Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma.
Dheilly, Elie; Battistello, Elena; Katanayeva, Natalya; Sungalee, Stephanie; Michaux, Justine; Duns, Gerben; Wehrle, Sarah; Sordet-Dessimoz, Jessica; Mina, Marco; Racle, Julien; Farinha, Pedro; Coukos, George; Gfeller, David; Mottok, Anja; Kridel, Robert; Correia, Bruno E; Steidl, Christian; Bassani-Sternberg, Michal; Ciriello, Giovanni; Zoete, Vincent; Oricchio, Elisa.
Afiliación
  • Dheilly E; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, 1015 Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland.
  • Battistello E; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, 1015 Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Department of Computational Biology, University of Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatic
  • Katanayeva N; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, 1015 Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland.
  • Sungalee S; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, 1015 Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland.
  • Michaux J; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne, Lausanne, Switzerland; Department of Oncology, University Hospital of Lausanne, Lausanne, Switzerland.
  • Duns G; Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, BC, Canada.
  • Wehrle S; Institute of Bioengineering, EPFL, 1015 Lausanne, Switzerland.
  • Sordet-Dessimoz J; Histology Core Facility, EPFL, 1015 Lausanne, Switzerland.
  • Mina M; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Department of Computational Biology, University of Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland.
  • Racle J; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland; Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne, Lausanne, Switzerland; Department of Oncology, University Hospital of Lausanne,
  • Farinha P; Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, BC, Canada.
  • Coukos G; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne, Lausanne, Switzerland; Department of Oncology, University Hospital of Lausanne, Lausanne, Switzerland.
  • Gfeller D; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland; Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne, Lausanne, Switzerland; Department of Oncology, University Hospital of Lausanne,
  • Mottok A; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Germany.
  • Kridel R; Princess Margaret Cancer Center, Toronto, Canada.
  • Correia BE; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland; Institute of Bioengineering, EPFL, 1015 Lausanne, Switzerland.
  • Steidl C; Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, BC, Canada.
  • Bassani-Sternberg M; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne, Lausanne, Switzerland; Department of Oncology, University Hospital of Lausanne, Lausanne, Switzerland.
  • Ciriello G; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Department of Computational Biology, University of Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland.
  • Zoete V; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland; Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne, Lausanne, Switzerland; Molecular Modeling Group, SIB, Lausanne, Switzerland.
  • Oricchio E; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, 1015 Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland. Electronic address: elisa.oricchio@epfl.ch.
Cancer Cell ; 37(5): 674-689.e12, 2020 05 11.
Article en En | MEDLINE | ID: mdl-32330455
ABSTRACT
Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We found that follicular lymphoma patients harbor a recurrent hotspot mutation targeting tyrosine 132 (Y132D) in cathepsin S (CTSS) that enhances protein activity. CTSS regulates antigen processing and CD4+ and CD8+ T cell-mediated immune responses. Loss of CTSS activity reduces lymphoma growth by limiting communication with CD4+ T follicular helper cells while inducing antigen diversification and activation of CD8+ T cells. Overall, our results suggest that CTSS inhibition has non-redundant therapeutic potential to enhance anti-tumor immune responses in indolent and aggressive lymphomas.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Linfoma no Hodgkin / Linfocitos T CD4-Positivos / Catepsinas / Presentación de Antígeno / Linfocitos T CD8-positivos / Microambiente Tumoral / Mutación Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Linfoma no Hodgkin / Linfocitos T CD4-Positivos / Catepsinas / Presentación de Antígeno / Linfocitos T CD8-positivos / Microambiente Tumoral / Mutación Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article