Serum biotin level during pregnancy is associated with fetal growth and preterm delivery.
J Med Invest
; 67(1.2): 170-173, 2020.
Article
en En
| MEDLINE
| ID: mdl-32378602
ABSTRACT
Backgroundâ
â
Biotin is a water-soluble vitamin that plays various biological roles through histone modification, such as immune functions and fetal growth. Mammalian maternal biotin deficiency during gestation induces fetal growth restriction. Preterm infants are known to be marginal biotin deficiency. However, studies on the biotin status of pregnant women under various conditions are lacking. Methodâ
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This was a retrospective case control study to analyze serum biotin concentration during pregnancy and cord blood in normal pregnancy, preterm delivery and small-for-gestational-age (SGA). Resultsâ
â
Twenty pregnant women with normal term delivery, 35 with preterm delivery, 24 with SGA, and 10 non-pregnant adult women were enrolled. Serum biotin concentrations of pregnant women remained low from first to third trimester. The levels of serum biotin in cord blood showed a significant positive correlation with gestational age, and that of pregnant women showed a weak positive correlation with gestational age. The maternal serum biotin levels during second and third trimester of SGA group were significantly lower than those of normal term delivery. Conclusionâ
â
This study suggests that maternal biotin deficiency during pregnancy might be the risk of preterm labor or fetal growth restriction. Further studies are required to clarify the roles of biotin in perinatal medicine. J. Med. Invest. 67 170-173, February, 2020.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Biotina
/
Embarazo
/
Nacimiento Prematuro
/
Desarrollo Fetal
Tipo de estudio:
Etiology_studies
/
Observational_studies
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Risk_factors_studies
Idioma:
En
Revista:
J Med Invest
Asunto de la revista:
MEDICINA
Año:
2020
Tipo del documento:
Article