Disulfiram Treatment Normalizes Body Weight in Obese Mice.
Cell Metab
; 32(2): 203-214.e4, 2020 08 04.
Article
en En
| MEDLINE
| ID: mdl-32413333
ABSTRACT
Obesity is a top public health concern, and a molecule that safely treats obesity is urgently needed. Disulfiram (known commercially as Antabuse), an FDA-approved treatment for chronic alcohol addiction, exhibits anti-inflammatory properties and helps protect against certain types of cancer. Here, we show that in mice disulfiram treatment prevented body weight gain and abrogated the adverse impact of an obesogenic diet on insulin responsiveness while mitigating liver steatosis and pancreatic islet hypertrophy. Additionally, disulfiram treatment reversed established diet-induced obesity and metabolic dysfunctions in middle-aged mice. Reductions in feeding efficiency and increases in energy expenditure were associated with body weight regulation in response to long-term disulfiram treatment. Loss of fat tissue and an increase in liver fenestrations were also observed in rats on disulfiram. Given the potent anti-obesogenic effects in rodents, repurposing disulfiram in the clinic could represent a new strategy to treat obesity and its metabolic comorbidities.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Peso Corporal
/
Fármacos Antiobesidad
/
Disulfiram
/
Obesidad
Idioma:
En
Revista:
Cell Metab
Asunto de la revista:
METABOLISMO
Año:
2020
Tipo del documento:
Article