Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders.

Gassowska-Dobrowolska, Magdalena; Cieslik, Magdalena; Czapski, Grzegorz Arkadiusz; Jesko, Henryk; Frontczak-Baniewicz, Malgorzata; Gewartowska, Magdalena; Dominiak, Agnieszka; Polowy, Rafal; Filipkowski, Robert Kuba; Babiec, Lidia; Adamczyk, Agata

Gassowska-Dobrowolska, Magdalena; Cieslik, Magdalena; Czapski, Grzegorz Arkadiusz; Jesko, Henryk; Frontczak-Baniewicz, Malgorzata; Gewartowska, Magdalena; Dominiak, Agnieszka; Polowy, Rafal; Filipkowski, Robert Kuba; Babiec, Lidia; Adamczyk, Agata.

Afiliación

Gassowska-Dobrowolska M; Department of Cellular Signalling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Cieslik M; Department of Cellular Signalling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Czapski GA; Department of Cellular Signalling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Jesko H; Department of Cellular Signalling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Frontczak-Baniewicz M; Electron Microscopy Platform, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Gewartowska M; Electron Microscopy Platform, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Dominiak A; Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland.
Polowy R; Behavior and Metabolism Research Laboratory, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5 St, 02-106 Warsaw, Poland.
Filipkowski RK; Behavior and Metabolism Research Laboratory, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5 St, 02-106 Warsaw, Poland.
Babiec L; Department of Cellular Signalling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Adamczyk A; Department of Cellular Signalling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.

Int J Mol Sci ; 21(10)2020 May 18.

Article en En | MEDLINE | ID: mdl-32443651

Asunto(s)

Trastorno del Espectro Autista/inducido químicamente; Microglía/efectos de los fármacos; Efectos Tardíos de la Exposición Prenatal; Sinapsis/efectos de los fármacos; Ácido Valproico/efectos adversos; Animales; Anticonvulsivantes/efectos adversos; Conducta Animal/efectos de los fármacos; Encéfalo/efectos de los fármacos; Encéfalo/metabolismo; Encéfalo/patología; Femenino; Inflamación; Masculino; Microglía/metabolismo; Microglía/patología; Estrés Oxidativo; Embarazo; Ratas; Sinapsis/patología; Ácido Valproico/toxicidad

Palabras clave

autism spectrum disorders (ASD); microglia; neuroinflammation; oxidative stress; pre- and postsynaptic proteins; synaptic ultrastructure; synaptopathology; valproic acid (VPA)

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Sinapsis / Ácido Valproico / Microglía / Trastorno del Espectro Autista Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article

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