Variability in the efficacy of a standardized antenatal steroid treatment was independent of maternal or fetal plasma drug levels: evidence from a sheep model of pregnancy.

Takahashi, Tsukasa; Saito, Masatoshi; Schmidt, Augusto F; Usuda, Haruo; Takahashi, Yuki; Watanabe, Shimpei; Hanita, Takushi; Sato, Shinichi; Kumagai, Yusaku; Koshinami, Shota; Ikeda, Hideyuki; Carter, Sean; Clarke, Michael; Fee, Erin L; Yaegashi, Nobuo; Newnham, John P; Jobe, Alan H; Kemp, Matthew W

Takahashi, Tsukasa; Saito, Masatoshi; Schmidt, Augusto F; Usuda, Haruo; Takahashi, Yuki; Watanabe, Shimpei; Hanita, Takushi; Sato, Shinichi; Kumagai, Yusaku; Koshinami, Shota; Ikeda, Hideyuki; Carter, Sean; Clarke, Michael; Fee, Erin L; Yaegashi, Nobuo; Newnham, John P; Jobe, Alan H; Kemp, Matthew W.

Afiliación

Takahashi T; Division of Obstetrics and Gynecology, the University of Western Australia, Perth, Western Australia, Australia; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan. Electronic address: tsukasa.takahashi@research.uwa.edu.au.
Saito M; Division of Obstetrics and Gynecology, the University of Western Australia, Perth, Western Australia, Australia; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Schmidt AF; Miller School of Medicine, University of Miami, Miami, FL.
Usuda H; Division of Obstetrics and Gynecology, the University of Western Australia, Perth, Western Australia, Australia.
Takahashi Y; Division of Obstetrics and Gynecology, the University of Western Australia, Perth, Western Australia, Australia; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Watanabe S; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Hanita T; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Sato S; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Kumagai Y; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Koshinami S; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Ikeda H; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Carter S; Division of Obstetrics and Gynecology, the University of Western Australia, Perth, Western Australia, Australia.
Clarke M; Metabolomics Australia, Center for Microscopy, Characterization and Analysis, the University of Western Australia, Perth, Western Australia, Australia.
Fee EL; Division of Obstetrics and Gynecology, the University of Western Australia, Perth, Western Australia, Australia.
Yaegashi N; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Newnham JP; Division of Obstetrics and Gynecology, the University of Western Australia, Perth, Western Australia, Australia.
Jobe AH; Division of Obstetrics and Gynecology, the University of Western Australia, Perth, Western Australia, Australia; Perinatal Research, Department of Pediatrics, Cincinnati Children's Hospital Medical Centre, University of Cincinnati, Cincinnati, OH.
Kemp MW; Division of Obstetrics and Gynecology, the University of Western Australia, Perth, Western Australia, Australia; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan; School of Veterinary and Life Sciences, Murdoch University, Perth, Western Australia, Australia.

Am J Obstet Gynecol ; 223(6): 921.e1-921.e10, 2020 12.

Article en En | MEDLINE | ID: mdl-32445634

Asunto(s)

Betametasona/análogos & derivados; Madurez de los Órganos Fetales/efectos de los fármacos; Glucocorticoides/farmacología; Pulmón/efectos de los fármacos; Animales; Acuaporina 1/efectos de los fármacos; Acuaporina 1/genética; Acuaporina 5/efectos de los fármacos; Acuaporina 5/genética; Betametasona/sangre; Betametasona/farmacología; Análisis de los Gases de la Sangre; Dióxido de Carbono; Canales Epiteliales de Sodio/efectos de los fármacos; Canales Epiteliales de Sodio/genética; Femenino; Madurez de los Órganos Fetales/genética; Glucocorticoides/sangre; Pulmón/metabolismo; Pulmón/fisiopatología; Rendimiento Pulmonar/efectos de los fármacos; Espectrometría de Masas; Intercambio Materno-Fetal; Presión Parcial; Atención Perinatal; Reacción en Cadena de la Polimerasa; Embarazo; Nacimiento Prematuro; Atención Prenatal; Proteína A Asociada a Surfactante Pulmonar/efectos de los fármacos; Proteína A Asociada a Surfactante Pulmonar/genética; Proteína B Asociada a Surfactante Pulmonar/efectos de los fármacos; Proteína B Asociada a Surfactante Pulmonar/genética; Proteína C Asociada a Surfactante Pulmonar/efectos de los fármacos; Proteína C Asociada a Surfactante Pulmonar/genética; ARN Mensajero/efectos de los fármacos; ARN Mensajero/metabolismo; Distribución Aleatoria; Respiración Artificial; Ovinos

Palabras clave

betamethasone; fetus; glucocorticoid; lamb; lung maturation; pharmacokinetics; preterm birth; protein binding; sheep

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Betametasona / Madurez de los Órganos Fetales / Glucocorticoides / Pulmón Tipo de estudio: Guideline / Prognostic_studies Idioma: En Revista: Am J Obstet Gynecol Año: 2020 Tipo del documento: Article

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