mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment.

Martin, Pierre-Yves; Doly, Stéphane; Hamieh, Al Mahdy; Chapuy, Eric; Canale, Vittorio; Drop, Marcin; Chaumont-Dubel, Séverine; Bantreil, Xavier; Lamaty, Frédéric; Bojarski, Andrzej J; Zajdel, Pawel; Eschalier, Alain; Marin, Philippe; Courteix, Christine

Martin, Pierre-Yves; Doly, Stéphane; Hamieh, Al Mahdy; Chapuy, Eric; Canale, Vittorio; Drop, Marcin; Chaumont-Dubel, Séverine; Bantreil, Xavier; Lamaty, Frédéric; Bojarski, Andrzej J; Zajdel, Pawel; Eschalier, Alain; Marin, Philippe; Courteix, Christine.

Afiliación

Martin PY; Université Clermont Auvergne, INSERM U1107, NEURO-DOL, F-63000, Clermont-Ferrand, France.
Doly S; Université Clermont Auvergne, INSERM U1107, NEURO-DOL, F-63000, Clermont-Ferrand, France.
Hamieh AM; Université Clermont Auvergne, INSERM U1107, NEURO-DOL, F-63000, Clermont-Ferrand, France.
Chapuy E; Université Clermont Auvergne, INSERM U1107, NEURO-DOL, F-63000, Clermont-Ferrand, France.
Canale V; Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland.
Drop M; Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland; IBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France.
Chaumont-Dubel S; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.
Bantreil X; IBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France.
Lamaty F; IBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France.
Bojarski AJ; Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343, Krakow, Poland.
Zajdel P; Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland.
Eschalier A; Université Clermont Auvergne, INSERM U1107, NEURO-DOL, F-63000, Clermont-Ferrand, France.
Marin P; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.
Courteix C; Université Clermont Auvergne, INSERM U1107, NEURO-DOL, F-63000, Clermont-Ferrand, France. Electronic address: christine.courteix@uca.fr.

Prog Neurobiol ; 193: 101846, 2020 10.

Article en En | MEDLINE | ID: mdl-32512114

Asunto(s)

Disfunción Cognitiva; Hiperalgesia; Neuralgia; Nocicepción; Receptores de Serotonina; Serotoninérgicos/farmacología; Serina-Treonina Quinasas TOR; Animales; Conducta Animal/efectos de los fármacos; Disfunción Cognitiva/tratamiento farmacológico; Disfunción Cognitiva/etiología; Disfunción Cognitiva/metabolismo; Modelos Animales de Enfermedad; Células HEK293; Humanos; Hiperalgesia/tratamiento farmacológico; Hiperalgesia/metabolismo; Masculino; Ratones Endogámicos C57BL; Ratones Transgénicos; Neuralgia/complicaciones; Neuralgia/tratamiento farmacológico; Neuralgia/metabolismo; Nocicepción/efectos de los fármacos; Ratas; Ratas Sprague-Dawley; Receptores de Serotonina/efectos de los fármacos; Receptores de Serotonina/metabolismo; Serotoninérgicos/administración & dosificación; Serina-Treonina Quinasas TOR/efectos de los fármacos; Serina-Treonina Quinasas TOR/metabolismo

Palabras clave

5-HT(6) receptor; Cognitive deficit; Constitutive activity; Inverse agonist; Neuropathic pain; mTOR

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Receptores de Serotonina / Serotoninérgicos / Serina-Treonina Quinasas TOR / Nocicepción / Disfunción Cognitiva / Hiperalgesia / Neuralgia Tipo de estudio: Etiology_studies / Prognostic_studies Idioma: En Revista: Prog Neurobiol Año: 2020 Tipo del documento: Article

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