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Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone.
Patel, Niki R; Nawrat, Christopher C; McLaughlin, Mark; Xu, Yingju; Huffman, Mark A; Yang, Hao; Li, Hongming; Whittaker, Aaron M; Andreani, Teresa; Lévesque, François; Fryszkowska, Anna; Brunskill, Andrew; Tschaen, David M; Maloney, Kevin M.
Afiliación
  • Patel NR; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Nawrat CC; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • McLaughlin M; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Xu Y; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Huffman MA; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Yang H; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Li H; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Whittaker AM; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Andreani T; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Lévesque F; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Fryszkowska A; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Brunskill A; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Tschaen DM; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Maloney KM; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Org Lett ; 22(12): 4659-4664, 2020 06 19.
Article en En | MEDLINE | ID: mdl-32516536
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article