Lung and Eye Disease Develop Concurrently in Supplemental Oxygen-Exposed Neonatal Mice.
Am J Pathol
; 190(9): 1801-1812, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-32526165
ABSTRACT
Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are two debilitating disorders that develop in preterm infants exposed to supplemental oxygen to prevent respiratory failure. Both can lead to lifelong disabilities, such as chronic obstructive pulmonary disease and vision loss. Due to the lack of a standard experimental model of coincident disease, the underlying associations between BPD and ROP are not well characterized. To address this gap, we used the robust mouse model of oxygen-induced retinopathy exposing C57BL/6 mice to 75% oxygen from postnatal day 7 to 12. The cardinal features of ROP were replicated by this strategy, and the lungs of the same mice were simultaneously examined for evidence of BPD-like lung injury, investigating both the short- and long-term effects of early-life supplemental oxygen exposure. At postnatal days 12 and 18, mild lung disease was evident by histopathologic analysis together with the expected vasculopathy in the inner retina. At later time points, the lung lesion had progressed to severe airspace enlargement and alveolar simplification, with concurrent thinning in the outer layer of the retina. In addition, critical angiogenic oxidative stress and inflammatory factors reported to be dysregulated in ROP were similarly impaired in the lungs. These data shed new light on the interconnectedness of these two neonatal disorders, holding potential for the discovery of novel targets to treat BPD and ROP.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Oxígeno
/
Terapia por Inhalación de Oxígeno
/
Retinopatía de la Prematuridad
/
Displasia Broncopulmonar
/
Modelos Animales de Enfermedad
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Idioma:
En
Revista:
Am J Pathol
Año:
2020
Tipo del documento:
Article