Structure and function of a flavin-dependent S-monooxygenase from garlic (<i>Allium sativum</i>).

Valentino, Hannah; Campbell, Ashley C; Schuermann, Jonathan P; Sultana, Nazneen; Nam, Han G; LeBlanc, Sophie; Tanner, John J; Sobrado, Pablo

Structure and function of a flavin-dependent S-monooxygenase from garlic (Allium sativum).

Valentino, Hannah; Campbell, Ashley C; Schuermann, Jonathan P; Sultana, Nazneen; Nam, Han G; LeBlanc, Sophie; Tanner, John J; Sobrado, Pablo.

Afiliación

Valentino H; Department of Biochemistry, Virginia Tech, Blacksburg, Virginia, USA.
Campbell AC; Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia, USA.
Schuermann JP; Department of Biochemistry, University of Missouri, Columbia, Missouri, USA.
Sultana N; Northeastern Collaborative Access Team, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA.
Nam HG; Department of Biochemistry, Virginia Tech, Blacksburg, Virginia, USA.
LeBlanc S; Department of Biochemistry, Virginia Tech, Blacksburg, Virginia, USA.
Tanner JJ; Department of Biochemistry, Virginia Tech, Blacksburg, Virginia, USA.
Sobrado P; Department of Biochemistry, University of Missouri, Columbia, Missouri, USA psobrado@vt.edu tannerjj@missouri.edu.

J Biol Chem ; 295(32): 11042-11055, 2020 08 07.

Article en En | MEDLINE | ID: mdl-32527723

Asunto(s)

Ajo/enzimología; Oxigenasas/metabolismo; Biopolímeros/metabolismo; Cisteína/metabolismo; Disulfuros; Flavina-Adenina Dinucleótido/metabolismo; Peróxido de Hidrógeno/metabolismo; Hidroxilación; Cinética; NADP/metabolismo; Oxidación-Reducción; Oxigenasas/química; Oxigenasas/aislamiento & purificación; Conformación Proteica; Relación Estructura-Actividad; Especificidad por Sustrato; Ácidos Sulfínicos/metabolismo

Palabras clave

C4a-hydroperoxyflavin; FAD; S-oxygenation; allicin; allyl mercaptan; class B monooxygenases; flavin; flavin-dependent monooxygenases; garlic (Allium sativum); hydroxylation; natural product; natural product biosynthesis; oxidation-reduction (redox); plant biochemistry; structure-function; sulfenic acid

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Oxigenasas / Ajo Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Oxigenasas / Ajo Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article