Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective.

Jackson, Christopher B; Turnbull, Doug M; Minczuk, Michal; Gammage, Payam A

Jackson, Christopher B; Turnbull, Doug M; Minczuk, Michal; Gammage, Payam A.

Afiliación

Jackson CB; Stem Cells and Metabolism, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.
Turnbull DM; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Minczuk M; MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Gammage PA; CRUK Beatson Institute, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. Electronic address: payam.gammage@glasgow.ac.uk.

Trends Mol Med ; 26(7): 698-709, 2020 07.

Article en En | MEDLINE | ID: mdl-32589937

Asunto(s)

ADN Mitocondrial/genética; Heteroplasmia/genética; Mitocondrias/genética; Animales; Humanos; Enfermedades Mitocondriales/genética; Mutación/genética

Palabras clave

gene therapy; heteroplasmy; mitoTALEN; mitochondrial disease; mtDNA; mtZFN

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: ADN Mitocondrial / Heteroplasmia / Mitocondrias Idioma: En Revista: Trends Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article

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