Nanoparticles Loaded with a New Thiourea Derivative: Development and <i>In vitro</i> Evaluation Against <i>Leishmania amazonensis</i>.

Meireles, Paloma Wetler; de Souza, Dandara Paiva Barroso; Rezende, Marianne Grilo; Borsodi, Maria Paula Gonçalves; de Oliveira, Douglas Escrivani; da Silva, Luiz Cláudio Rodrigues Pereira; de Souza, Alessandra Mendonça Teles; Viana, Gil Mendes; Rodrigues, Carlos Rangel; do Carmo, Flavia Almada; de Sousa, Valeria Pereira; Rossi-Bergmann, Bartira; Cabral, Lucio Mendes

Nanoparticles Loaded with a New Thiourea Derivative: Development and In vitro Evaluation Against Leishmania amazonensis.

Meireles, Paloma Wetler; de Souza, Dandara Paiva Barroso; Rezende, Marianne Grilo; Borsodi, Maria Paula Gonçalves; de Oliveira, Douglas Escrivani; da Silva, Luiz Cláudio Rodrigues Pereira; de Souza, Alessandra Mendonça Teles; Viana, Gil Mendes; Rodrigues, Carlos Rangel; do Carmo, Flavia Almada; de Sousa, Valeria Pereira; Rossi-Bergmann, Bartira; Cabral, Lucio Mendes.

Afiliación

Meireles PW; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
de Souza DPB; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Rezende MG; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Borsodi MPG; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
de Oliveira DE; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
da Silva LCRP; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
de Souza AMT; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Viana GM; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Rodrigues CR; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
do Carmo FA; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
de Sousa VP; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Rossi-Bergmann B; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Cabral LM; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Curr Drug Deliv ; 17(8): 694-702, 2020.

Article en En | MEDLINE | ID: mdl-32621717

Asunto(s)

Antiprotozoarios/administración & dosificación; Portadores de Fármacos/química; Leishmania mexicana/efectos de los fármacos; Leishmaniasis Cutánea/tratamiento farmacológico; Tiourea/administración & dosificación; Animales; Antiprotozoarios/farmacocinética; Antiprotozoarios/toxicidad; Modelos Animales de Enfermedad; Liberación de Fármacos; Humanos; Leishmaniasis Cutánea/parasitología; Macrófagos/parasitología; Ratones; Nanopartículas/química; Pruebas de Sensibilidad Parasitaria; Tamaño de la Partícula; Copolímero de Ácido Poliláctico-Ácido Poliglicólico/química; Cultivo Primario de Células; Tiourea/análogos & derivados; Tiourea/farmacocinética; Tiourea/toxicidad; Pruebas de Toxicidad Aguda

Palabras clave

Leishmaniasis; PLGA; amastigotes; cytotoxicity; macrophages; polymeric nanoparticles; promastigotes; thiourea

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tiourea / Leishmania mexicana / Portadores de Fármacos / Leishmaniasis Cutánea / Antiprotozoarios Idioma: En Revista: Curr Drug Deliv Asunto de la revista: FARMACIA / FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2020 Tipo del documento: Article

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