Broadband Entrainment of Striatal Low-Threshold Spike Interneurons.
Front Neural Circuits
; 14: 36, 2020.
Article
en En
| MEDLINE
| ID: mdl-32655378
ABSTRACT
Striatal interneurons and spiny projection (SP) neurons are differentially tuned to spectral components of their input. Previous studies showed that spike responses of somatostatin/NPY-expressing low threshold spike (LTS) interneurons have broad frequency tuning, setting these cells apart from other striatal GABAergic interneurons and SP neurons. We investigated the mechanism of LTS interneuron spiking resonance and its relationship to non-spiking membrane impedance resonance, finding that abolition of impedance resonance did not alter spiking resonance. Because LTS interneurons are pacemakers whose rhythmic firing is perturbed by synaptic input, we tested the hypothesis that their spiking resonance arises from their phase resetting properties. Phase resetting curves (PRCs) were measured in LTS interneurons and SP neurons and used to make phase-oscillator models of both cell types. The models reproduced the broad tuning of LTS interneurons, and the differences from SP neurons. The spectral components of the PRC predicted each cell's sensitivity to corresponding input frequencies. LTS interneuron PRCs contain larger high-frequency components than SP neuron PRCs, providing enhanced responses to input frequencies above the cells' average firing rates. Thus, LTS cells can be entrained by input oscillations to which SP neurons are less responsive. These findings suggest that feedforward inhibition by LTS interneurons may regulate SP neurons' entrainment by oscillatory afferents.
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Base de datos:
MEDLINE
Asunto principal:
Relojes Biológicos
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Potenciales de Acción
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Cuerpo Estriado
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Interneuronas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Front Neural Circuits
Año:
2020
Tipo del documento:
Article