CRMP-5-IgG Antibody: role in the bilateral uveitis with swollen disc.
Rom J Ophthalmol
; 64(2): 217-221, 2020.
Article
en En
| MEDLINE
| ID: mdl-32685790
ABSTRACT
Autoimmunity against collapsin response-mediator protein-5 (anti-CRMP-5) has been associated with ocular inflammation in paraneoplastic syndrome. We present a 59-year-old Caucasian man with optic neuritis and vitreous cells in both eyes (OU), at different stages. Despite the fact that the patient did not have any systemic disease, we suspected a paraneoplastic syndrome and requested CRMP-5-IgG and a mediastinoscopy. After performing the tests, a small cell lung carcinoma was diagnosed. Autoantibody CRMP-5-IgG positivity and optic neuritis combined with vitreous inflammation was defined as a paraneoplastic entity, avoiding vitreous biopsy and allowing us to suspect malignancy before systemic symptoms appeared.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Uveítis
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Inmunoglobulina G
/
Angiografía con Fluoresceína
/
Campos Visuales
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Papiledema
/
Hidrolasas
/
Proteínas Asociadas a Microtúbulos
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Rom J Ophthalmol
Año:
2020
Tipo del documento:
Article