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An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.
Luna, Lucas A; Lesecq, Zachary; White, Katharine A; Hoang, An; Scott, David A; Zagnitko, Olga; Bobkov, Andrey A; Barber, Diane L; Schiffer, Jamie M; Isom, Daniel G; Sohl, Christal D.
Afiliación
  • Luna LA; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, U.S.A.
  • Lesecq Z; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, U.S.A.
  • White KA; Harper Cancer Research Institute, Department of Chemistry and Biochemistry, University of Notre Dame, South Bend, IN 46617, U.S.A.
  • Hoang A; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, U.S.A.
  • Scott DA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A.
  • Zagnitko O; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A.
  • Bobkov AA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A.
  • Barber DL; Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143, U.S.A.
  • Schiffer JM; Janssen Research and Development, 3210 Merryfield Row, San Diego, CA 92121, U.S.A.
  • Isom DG; Department of Pharmacology, Sylvester Comprehensive Cancer Center, and Center for Computational Sciences, University of Miami, Miami, FL 33136, U.S.A.
  • Sohl CD; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, U.S.A.
Biochem J ; 477(16): 2999-3018, 2020 08 28.
Article en En | MEDLINE | ID: mdl-32729927
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Glutaratos / Isocitrato Deshidrogenasa / Isocitratos / Mutación Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Biochem J Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Glutaratos / Isocitrato Deshidrogenasa / Isocitratos / Mutación Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Biochem J Año: 2020 Tipo del documento: Article