Genetics and Epigenetics of Sex Bias: Insights from Human Cancer and Autoimmunity.
Trends Genet
; 36(9): 650-663, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-32736810
ABSTRACT
High-throughput sequencing and genome-wide association studies have revealed a sex bias in human diseases. The underlying molecular mechanisms remain, however, unknown. Here, we cover recent advances in cancer and autoimmunity focusing on intrinsic genetic and epigenetic differences underlying sex biases in human disease. These studies reveal a central role of genome regulatory mechanisms including genome repair, chromosome folding, and epigenetic regulation in dictating the sex bias. These highlight the importance of considering sex as a variable in both basic science and clinical investigations. Understanding the molecular mechanisms underlying sex bias in human diseases will be instrumental in making a first step forwards into the era of personalized medicine.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Autoinmunidad
/
Epigénesis Genética
/
Estudio de Asociación del Genoma Completo
/
Medicina de Precisión
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Trends Genet
Asunto de la revista:
GENETICA
Año:
2020
Tipo del documento:
Article