The Effects of Antipsychotics on the Synaptic Plasticity Gene <i>Homer1a</i> Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted.

Iasevoli, Felice; Buonaguro, Elisabetta Filomena; Avagliano, Camilla; Barone, Annarita; Eramo, Anna; Vellucci, Licia; de Bartolomeis, Andrea

The Effects of Antipsychotics on the Synaptic Plasticity Gene Homer1a Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted.

Iasevoli, Felice; Buonaguro, Elisabetta Filomena; Avagliano, Camilla; Barone, Annarita; Eramo, Anna; Vellucci, Licia; de Bartolomeis, Andrea.

Afiliación

Iasevoli F; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.
Buonaguro EF; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.
Avagliano C; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.
Barone A; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.
Eramo A; Lundbeck LLC, Deerfield, IL 60015, USA.
Vellucci L; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.
de Bartolomeis A; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, 80131 Napoli, Italy.

Int J Mol Sci ; 21(15)2020 Aug 03.

Article en En | MEDLINE | ID: mdl-32756473

Asunto(s)

Antipsicóticos/farmacología; Encéfalo/efectos de los fármacos; Proteínas de Andamiaje Homer/genética; Plasticidad Neuronal/efectos de los fármacos; Animales; Antipsicóticos/efectos adversos; Encéfalo/metabolismo; Mapeo Encefálico; Dibenzocicloheptenos; Relación Dosis-Respuesta a Droga; Duración de la Terapia; Haloperidol/farmacología; Compuestos Heterocíclicos de 4 o más Anillos/farmacología; Humanos; Hibridación in Situ; Modelos Animales; Plasticidad Neuronal/genética; Olanzapina/farmacología; Densidad Postsináptica/efectos de los fármacos; Densidad Postsináptica/genética; Ratas; Distribución Tisular/efectos de los fármacos

Palabras clave

asenapine; dopamine; gene expression; glutamate; haloperidol; olanzapine; psychosis; synaptic plasticity; treatment resistant schizophrenia

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antipsicóticos / Encéfalo / Proteínas de Andamiaje Homer / Plasticidad Neuronal Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article

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