Quantitation of 2-hydroxyglutarate in human plasma via LC-MS/MS using a surrogate analyte approach.

Yin, Feng; Ling, Yonghua; Keller, Jennifer; Kraus, Dennis; Narayanaswamy, Rohini; Mangus, Heidi; Li, Fumin; Yang, Hua; Liu, Guowen

Yin, Feng; Ling, Yonghua; Keller, Jennifer; Kraus, Dennis; Narayanaswamy, Rohini; Mangus, Heidi; Li, Fumin; Yang, Hua; Liu, Guowen.

Afiliación

Yin F; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, MA 02139, USA.
Ling Y; PPD Inc., 3230 Deming Way, Middleton, WI 53562, USA.
Keller J; PPD Inc., 3230 Deming Way, Middleton, WI 53562, USA.
Kraus D; PPD Inc., 3230 Deming Way, Middleton, WI 53562, USA.
Narayanaswamy R; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, MA 02139, USA.
Mangus H; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, MA 02139, USA.
Li F; PPD Inc., 3230 Deming Way, Middleton, WI 53562, USA.
Yang H; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, MA 02139, USA.
Liu G; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, MA 02139, USA.

Bioanalysis ; 12(16): 1149-1159, 2020 Aug.

Article en En | MEDLINE | ID: mdl-32757862

Asunto(s)

Cromatografía Liquida/métodos; Glutaratos/metabolismo; Espectrometría de Masas en Tándem/métodos; Humanos

Palabras clave

2-HG; 2-hydroxyglutarate; IDH inhibitor; LCMS/MS; endogenous biomarkers; human plasma; small molecule; surrogate analyte; validation

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cromatografía Liquida / Espectrometría de Masas en Tándem / Glutaratos Tipo de estudio: Guideline Idioma: En Revista: Bioanalysis Año: 2020 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google