Microfluidic lumen-based systems for advancing tubular organ modeling.
Chem Soc Rev
; 49(17): 6402-6442, 2020 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-32760967
ABSTRACT
Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and physiology of tubular organs. These technologies can mimic human pathophysiology and predict drug response, having profound implications for drug discovery and development. Herein, we review progress in the development of microfluidic lumen-based models from the 2000s to the present. The core of the review discusses models for mimicking blood vessels, the respiratory tract, the gastrointestinal tract, renal tubules, and liver sinusoids, and their application to modeling organ-specific diseases. We also highlight emerging application areas, such as the lymphatic system, and close the review discussing potential future directions.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ingeniería de Tejidos
/
Biomimética
/
Dispositivos Laboratorio en un Chip
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Chem Soc Rev
Año:
2020
Tipo del documento:
Article