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Microfluidic lumen-based systems for advancing tubular organ modeling.
Virumbrales-Muñoz, María; Ayuso, José M; Gong, Max M; Humayun, Mouhita; Livingston, Megan K; Lugo-Cintrón, Karina M; McMinn, Patrick; Álvarez-García, Yasmín R; Beebe, David J.
Afiliación
  • Virumbrales-Muñoz M; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
  • Ayuso JM; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA and Morgridge Institute for Research, Madison, WI, USA.
  • Gong MM; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA and Department of Biomedical Engineering, Trine University, Angola, IN, USA.
  • Humayun M; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
  • Livingston MK; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
  • Lugo-Cintrón KM; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
  • McMinn P; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
  • Álvarez-García YR; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
  • Beebe DJ; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA and Department of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, USA.
Chem Soc Rev ; 49(17): 6402-6442, 2020 Sep 01.
Article en En | MEDLINE | ID: mdl-32760967
ABSTRACT
Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and physiology of tubular organs. These technologies can mimic human pathophysiology and predict drug response, having profound implications for drug discovery and development. Herein, we review progress in the development of microfluidic lumen-based models from the 2000s to the present. The core of the review discusses models for mimicking blood vessels, the respiratory tract, the gastrointestinal tract, renal tubules, and liver sinusoids, and their application to modeling organ-specific diseases. We also highlight emerging application areas, such as the lymphatic system, and close the review discussing potential future directions.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ingeniería de Tejidos / Biomimética / Dispositivos Laboratorio en un Chip Tipo de estudio: Prognostic_studies Idioma: En Revista: Chem Soc Rev Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ingeniería de Tejidos / Biomimética / Dispositivos Laboratorio en un Chip Tipo de estudio: Prognostic_studies Idioma: En Revista: Chem Soc Rev Año: 2020 Tipo del documento: Article