Nanoencapsulation of triterpene 3ß,6ß,16ß-trihydroxylup-20(29)-ene from Combretum leprosum as strategy to improve its cytotoxicity against cancer cell lines.

Silva-Filho, Carlos J A; Freitas, Paulo G C; Oliveira, Fátima C E; Barbosa, Francisco G; Oliveira, Maria C F; Eloy, Josimar O; Pessoa, Cláudia; Mafezoli, Jair

Silva-Filho, Carlos J A; Freitas, Paulo G C; Oliveira, Fátima C E; Barbosa, Francisco G; Oliveira, Maria C F; Eloy, Josimar O; Pessoa, Cláudia; Mafezoli, Jair.

Afiliación

Silva-Filho CJA; Department of Organic and Inorganic Chemistry, Science Centre, Federal University of Ceará, 60455-970 Fortaleza, CE, Brazil.
Freitas PGC; Department of Pharmacy, Faculty of Pharmacy, Odontology and Nursing, Federal University of Ceará, 60430-372 Fortaleza, CE, Brazil.
Oliveira FCE; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil.
Barbosa FG; Department of Organic and Inorganic Chemistry, Science Centre, Federal University of Ceará, 60455-970 Fortaleza, CE, Brazil.
Oliveira MCF; Department of Organic and Inorganic Chemistry, Science Centre, Federal University of Ceará, 60455-970 Fortaleza, CE, Brazil.
Eloy JO; Department of Pharmacy, Faculty of Pharmacy, Odontology and Nursing, Federal University of Ceará, 60430-372 Fortaleza, CE, Brazil.
Pessoa C; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil.
Mafezoli J; Department of Organic and Inorganic Chemistry, Science Centre, Federal University of Ceará, 60455-970 Fortaleza, CE, Brazil. Electronic address: jmafez@ufc.br.

Bioorg Med Chem Lett ; 30(20): 127469, 2020 10 15.

Article en En | MEDLINE | ID: mdl-32768650

Asunto(s)

Antineoplásicos Fitogénicos/farmacología; Productos Biológicos/farmacología; Combretum/química; Antineoplásicos Fitogénicos/química; Antineoplásicos Fitogénicos/aislamiento & purificación; Productos Biológicos/química; Productos Biológicos/aislamiento & purificación; Cápsulas; Línea Celular; Proliferación Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Estructura Molecular; Hojas de la Planta/química; Relación Estructura-Actividad

Palabras clave

3ß,6ß,16ß-trihydroxylup-20(29)-ene; Combretum leprosum; Cytotoxic activity; Nanoparticles; Triterpene

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Productos Biológicos / Combretum / Antineoplásicos Fitogénicos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article

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