The IL1ß-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs).

Lappano, Rosamaria; Talia, Marianna; Cirillo, Francesca; Rigiracciolo, Damiano Cosimo; Scordamaglia, Domenica; Guzzi, Rita; Miglietta, Anna Maria; De Francesco, Ernestina Marianna; Belfiore, Antonino; Sims, Andrew H; Maggiolini, Marcello

Lappano, Rosamaria; Talia, Marianna; Cirillo, Francesca; Rigiracciolo, Damiano Cosimo; Scordamaglia, Domenica; Guzzi, Rita; Miglietta, Anna Maria; De Francesco, Ernestina Marianna; Belfiore, Antonino; Sims, Andrew H; Maggiolini, Marcello.

Afiliación

Lappano R; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy. rosamaria.lappano@unical.it.
Talia M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Cirillo F; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Rigiracciolo DC; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Scordamaglia D; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Guzzi R; Department of Physics, University of Calabria, 87036, Rende, Italy.
Miglietta AM; Regional Hospital Cosenza, 87100, Cosenza, Italy.
De Francesco EM; Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, 95122, Catania, Italy.
Belfiore A; Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, 95122, Catania, Italy.
Sims AH; MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XR, UK.
Maggiolini M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy. marcello.maggiolini@unical.it.

J Exp Clin Cancer Res ; 39(1): 153, 2020 Aug 10.

Article en En | MEDLINE | ID: mdl-32778144

Asunto(s)

Biomarcadores de Tumor/metabolismo; Neoplasias de la Mama/patología; Fibroblastos Asociados al Cáncer/patología; Regulación Neoplásica de la Expresión Génica; Hipoxia/fisiopatología; Interleucina-1beta/metabolismo; Receptores Tipo I de Interleucina-1/metabolismo; Apoptosis; Biomarcadores de Tumor/genética; Neoplasias de la Mama/genética; Neoplasias de la Mama/metabolismo; Fibroblastos Asociados al Cáncer/metabolismo; Proliferación Celular; Femenino; Perfilación de la Expresión Génica; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Interleucina-1beta/genética; Pronóstico; Receptores de Estrógenos/genética; Receptores de Estrógenos/metabolismo; Receptores Acoplados a Proteínas G/genética; Receptores Acoplados a Proteínas G/metabolismo; Receptores Tipo I de Interleucina-1/genética; Transducción de Señal; Células Tumorales Cultivadas; Microambiente Tumoral

Palabras clave

Breast cancer; Cancer-associated fibroblasts (CAFs); G protein estrogen receptor (GPER); Hypoxia; Hypoxia inducible factor-1α (HIF-1α); Interleukin-1ß (IL-ß)

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Interleucina-1beta / Receptores Tipo I de Interleucina-1 / Fibroblastos Asociados al Cáncer / Hipoxia Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Exp Clin Cancer Res Año: 2020 Tipo del documento: Article

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