Simultaneous Determination of Urine Methotrexate, 7-Hydroxy Methotrexate, Deoxyaminopteroic Acid, and 7-Hydroxy Deoxyaminopteroic Acid by UHPLC-MS/MS in Patients Receiving High-dose Methotrexate Therapy.

Mei, Shenghui; Cui, Yong; Zhang, Dongjie; Zeng, Chun; Ren, Xiaohui; Yu, Kefu; Lin, Song; Zhao, Zhigang

Mei, Shenghui; Cui, Yong; Zhang, Dongjie; Zeng, Chun; Ren, Xiaohui; Yu, Kefu; Lin, Song; Zhao, Zhigang.

Afiliación

Mei S; Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuan West Road, Fengtai District, Beijing, 100070, China.
Cui Y; Department of Clinical Pharmacology, College of Pharmaceutical Sciences, Capital Medical University, Beijing, 100045, China.
Zhang D; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuan West Road, Fengtai District, Beijing, 100070, China.
Zeng C; Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuan West Road, Fengtai District, Beijing, 100070, China.
Ren X; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuan West Road, Fengtai District, Beijing, 100070, China.
Yu K; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuan West Road, Fengtai District, Beijing, 100070, China.
Lin S; Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuan West Road, Fengtai District, Beijing, 100070, China.
Zhao Z; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuan West Road, Fengtai District, Beijing, 100070, China.

Anal Sci ; 36(12): 1479-1483, 2020 Dec 10.

Article en En | MEDLINE | ID: mdl-32801284

Asunto(s)

Cromatografía Líquida de Alta Presión; Metotrexato/análogos & derivados; Metotrexato/farmacología; Metotrexato/orina; Espectrometría de Masas en Tándem; Urinálisis/métodos; Relación Dosis-Respuesta a Droga; Humanos; Concentración de Iones de Hidrógeno; Factores de Tiempo

Palabras clave

7-hydroxy deoxyaminopteroic acid; 7-hydroxy methotrexate; UHPLC-MS/MS; deoxyaminopteroic acid; method development and validation; methotrexate; urine

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Metotrexato / Cromatografía Líquida de Alta Presión / Urinálisis / Espectrometría de Masas en Tándem Idioma: En Revista: Anal Sci Año: 2020 Tipo del documento: Article

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