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Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.
Wang, Guangyi; Dyatkina, Natalia; Prhavc, Marija; Williams, Caroline; Serebryany, Vladimir; Hu, Yujian; Huang, Yongfei; Wu, Xiangyang; Chen, Tongqian; Huang, Wensheng; Rajwanshi, Vivek K; Deval, Jerome; Fung, Amy; Jin, Zhinan; Stoycheva, Antitsa; Shaw, Kenneth; Gupta, Kusum; Tam, Yuen; Jekle, Andreas; Smith, David B; Beigelman, Leonid.
Afiliación
  • Wang G; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Dyatkina N; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Prhavc M; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Williams C; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Serebryany V; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Hu Y; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131, P. R. China.
  • Huang Y; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131, P. R. China.
  • Wu X; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131, P. R. China.
  • Chen T; Pharmaron Beijing, Co. Ltd., No. 6, TaiHe Road, BDA, Beijing 100176, P. R. China.
  • Huang W; Pharmaron Beijing, Co. Ltd., No. 6, TaiHe Road, BDA, Beijing 100176, P. R. China.
  • Rajwanshi VK; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Deval J; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Fung A; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Jin Z; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Stoycheva A; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Shaw K; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Gupta K; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Tam Y; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Jekle A; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Smith DB; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
  • Beigelman L; Janssen BioPharma, Inc., 260 E. Grand Avenue, South San Francisco, California 94080, United States.
J Med Chem ; 63(18): 10380-10395, 2020 09 24.
Article en En | MEDLINE | ID: mdl-32816483
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antivirales / ARN Polimerasas Dirigidas por ADN / Profármacos / Hepacivirus / Inhibidores Enzimáticos / Nucleótidos de Guanina Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antivirales / ARN Polimerasas Dirigidas por ADN / Profármacos / Hepacivirus / Inhibidores Enzimáticos / Nucleótidos de Guanina Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article