The role of diacylglycerol kinases in allergic airway disease.
Curr Opin Pharmacol
; 51: 50-58, 2020 04.
Article
en En
| MEDLINE
| ID: mdl-32836013
ABSTRACT
Asthma is an obstructive inflammatory airway disease. Airway obstruction is mediated by hyperresponsive airway smooth muscle cell contraction, which is induced and compounded by inflammation caused by T lymphocytes. One important signal transduction pathway that is involved in the activation of these cell types involves the generation of a lipid second messenger known as diacylglycerol (DAG). DAG levels are controlled in cells by a negative regulator known as DAG kinase (DGK). In this review, we discuss how the DAG signaling pathway attenuates the pathological function of immune cells and airway smooth muscle cells in allergic airway disease and asthma. Furthermore, we discuss how the enhancement of the DAG signaling pathway through the inhibition of DGK may represent a novel therapeutic strategy for these diseases.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Diacilglicerol Quinasa
/
Miocitos del Músculo Liso
/
Hipersensibilidad
/
Enfermedades Pulmonares
Idioma:
En
Revista:
Curr Opin Pharmacol
Asunto de la revista:
FARMACOLOGIA
Año:
2020
Tipo del documento:
Article